Monday, 19 August 2013

Malignant Sarcomatoid Mesothelioma

Considered as a variant of desmoplastic mesothelioma from sarcomatoid mesothelioma. This form is probably the most difficult of all mesotheliomas to diagnose. When desmoplastic mesothelioma attack or metastasize, the cells may appear very flat and can be misdiagnosed as benign fibrous tissue. Medical experts say this form should not be diagnosed by core needle biopsy. It's important to recognize that sarcomatoid malignant mesothelioma is sometimes difficult to diagnose based on histological methods. For example, cells of other types of lung cancer called sarcomatoid carcinomas are very similar in appearance (as well as other characteristics) for sarcomatoid malignant mesothelioma.

Unfortunately, sarcomatoid mesothelioma cells are known to be resistant to treatment, which may mean that a typical combination of surgery, radiation and chemotherapy did not work. Certain cell types may indicate a specific clinical trials and treatments that patients have available to them.

For this reason, if you are diagnosed with cancer and you know that you have been exposed to asbestos at some time in the past, obtaining a second diagnostic opinion may be important. Various types of cancers vary widely in terms of prognosis and treatment options, and if the wrong diagnosis, the patient can not receive the most appropriate treatment for their cancer .

How Mesothelioma is Diagnosed sarcomatoid ?

To diagnose as sarcomatoid mesothelioma cells, histological examination of tumor tissue performed. Tues sarcomatoid will often look very similar to other types of sarcomatoid cells, such as sarcomatoid carcinoma, or tumor that affects the epithelial cells of the body. Sarcomatoid mesothelioma is commonly misdiagnosed as pulmonary sarcomatoid carcinoma, a cancer that affects the lungs and produces symptoms almost identical with mesothelioma.

To that end, the immunohistochemical data is very important in differentiating cells of sarcomatoid mesothelioma from sarcomatoid carcinoma and other spindle cell type. Malignant mesothelioma cells are keratin-positive sarcomatoid, which means that cells will react with antibodies specific antikeratin used during the coloring process cell samples.

Desmoplastic mesothelioma

Even more difficult to diagnose than sarcomatoid mesothelioma, desmoplastic mesothelioma is considered as a variant of sarcomatoid subtype and also frequently misdiagnosed as benign (non-cancerous) fibrous tissue. Desmoplastic mesothelioma is a rare variant, making only 5 to 10 percent of all cases of malignant mesotheliomas.

How a cell sarcomatoid Affect Prognosis & Treatment?

While the sarcomatoid mesothelioma is the most common form of malignant mesothelioma, unfortunately, is considered the most lethal subtype because of the aggressive nature. Tues sarcomatoid mesothelioma treated with therapy similar to other subtypes, but sarcomatoid cells more resistant to treatment than epithelial or biphasic subtype.

Sarcomatoid mesothelioma cases are often especially resistant to chemotherapy. This response to treatment leads to poorer prognosis for patients diagnosed with this subtype, as well as survival time is reduced.

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